Table 3.
Health-related quality of life (EORTC QLQ-C30) outcome variables and mean differences at 6 and 4 months (95% CI)
| Outcome variable | 6 months |
14 months |
||||||
| n | Mean (CI) | Mean difference (95% CI) | p Value | n | Mean (CI) | Mean difference (95% CI) | p Value | |
| Global health status/quality of life | ||||||||
| Control group | 297 | 68.0 (65.5 to 70.5) | 246 | 72.8 (70.3 to 75.3) | ||||
| Intervention group | 281 | 69.3 (66.7 to 71.9) | 1.25 (−2.4 to 4.9) | 0.50 | 240 | 72.1 (69.6 to 74.7) | −0.71 (−4.3 to 2.8) | 0.69 |
| Physical functioning | ||||||||
| Control group | 294 | 79.0 (76.4 to 81.5) | 240 | 81.9 (79.3 to 84.5) | ||||
| Intervention group | 280 | 79.7 (77.1 to 82.4) | 0.77 (−2.9 to 4.4) | 0.68 | 234 | 82.0 (79.4 to 84.6) | −0.08 (−3.6 to 3.8) | 0.97 |
| Role functioning | ||||||||
| Control group | 291 | 71.3 (67.7 to 74.9) | 239 | 78.0 (74.4 to 81.7) | ||||
| Intervention group | 277 | 72.5 (68.8 to 76.1) | 1.18 (−3.9 to 6.3) | 0.65 | 235 | 78.8 (75.0 to 82.5) | 0.70 (−4.5 to 5.9) | 0.79 |
| Emotional functioning | ||||||||
| Control group | 293 | 80.5 (78.1 to 83.0) | 240 | 80.7 (77.9 to 83.4) | ||||
| Intervention group | 278 | 81.6 (79.1 to 84.1) | 1.02 (−2.5 to 4.5) | 0.57 | 238 | 80.8 (78.0 to 83.6) | 0.12 (−3.8 to 4.1) | 0.95 |
| Cognitive functioning | ||||||||
| Control group | 290 | 83.0 (80.5 to 85.5) | 245 | 82.6 (79.7 to 85.5) | ||||
| Intervention group | 278 | 83.9 (81.3 to 86.4) | 0.88 (−2.7 to 4.5) | 0.63 | 238 | 85.1 (82.1 to 88.2) | 2.53 (−1.7 to 6.7) | 0.24 |
| Social functioning | ||||||||
| Control group | 295 | 85.7 (83.0 to 88.4) | 242 | 88.2 (85.4 to 91.0) | ||||
| Intervention group | 280 | 86.0 (83.2 to 88.8) | 0.28 (−3.6 to 4.2) | 0.89 | 238 | 87.4 (84.6 to 90.3) | −0.77 (−4.8 to 3.2) | 0.71 |
| Fatigue | ||||||||
| Control group | 292 | 37.4 (34.3 to 40.6) | 244 | 32.1 (28.8 to 35.3) | ||||
| Intervention group | 279 | 34.2 (30.9 to 37.4) | −3.27 (−7.8 to 1.3) | 0.16 | 234 | 32.3 (28.9 to 35.6) | 0.23 (−4.5 to 4.9) | 0.92 |
| Nausea and vomiting | ||||||||
| Control group | 300 | 8.1 (6.1 to 10.0) | 244 | 5.5 (3.9 to 7.2) | ||||
| Intervention group | 284 | 8.0 (6.0 to 10.0) | −0.11 (−2.9 to 2.7) | 0.94 | 236 | 5.6 (3.9 to 7.3) | 0.05 (−2.3 to 2.4) | 0.97 |
| Pain | ||||||||
| Control group | 283 | 23.0 (19.8 to 20.2) | 241 | 21.9 (18.5 to 25.4) | ||||
| Intervention group | 274 | 22.0 (18.8 to 25.3) | −0.95 (−5.5 to 3.6) | 0.68 | 234 | 21.4 (17.8 to 24.9) | −0.56 (−5.5 to 4.4) | 0.83 |
| Dyspnoea | ||||||||
| Control group | 297 | 17.0 (13.9 to 20.2) | 245 | 13.2 (10.0 to 16.5) | ||||
| Intervention group | 286 | 17.9 (14.7 to 21.2) | 0.87 (−3.6 to 5.4) | 0.71 | 233 | 15.4 (11.9 to 18.8) | 2.11 (−2.6 to 6.8) | 0.38 |
| Insomnia | ||||||||
| Control group | 302 | 27.5 (24.0 to 31.0) | 248 | 29.6 (25.6 to 33.6) | ||||
| Intervention group | 285 | 27.3 (23.6 to 30.9) | −0.23 (−5.3 to 4.8) | 0.93 | 240 | 28.5 (24.4 to 32.6) | −1.08 (−6.8 to 4.6) | 0.71 |
| Appetite loss | ||||||||
| Control group | 301 | 14.1 (11.0 to 17.2) | 246 | 9.6 (7.1 to 12.2) | ||||
| Intervention group | 288 | 15.9 (12.7 to 19.0) | 1.79 (−2.7 to 6.2) | 0.43 | 239 | 7.9 (5.4 to 10.5) | −1.67 (−5.3 to 2.0) | 0.37 |
| Constipation | ||||||||
| Control group | 299 | 12.6 (9.7 to 15.5) | 248 | 11.9 (9.0 to 14.91) | ||||
| Intervention group | 284 | 11.3 (8.3 to 14.2) | −1.33 (−5.4 to 2.8) | 0.53 | 236 | 8.9 (5.9 to 11.9) | −3.03 (−5.5 to 2.8) | 0.16 |
| Diarrhoea | ||||||||
| Control group | 299 | 11.3 (8.8 to 13.9) | 250 | 11.4 (8.5 to 14.2) | ||||
| Intervention group | 284 | 11.4 (8.8 to 14.1) | 0.08 (−3.6 to 3.8) | 0.97 | 238 | 10.0 (7.0 to 13.0) | −1.38 (−5.5 to 2.8) | 0.51 |
| Financial difficulties | ||||||||
| Control group | 297 | 7.6 (5.4 to 9.8) | 242 | 6.5 (3.9 to 9.0) | ||||
| Intervention group | 284 | 8.0 (5.7 to 10.2) | 0.34 (−2.8 to 3.5) | 0.83 | 236 | 6.7 (4.1 to 9.4) | 0.27 (−3.4 to 4.0) | 0.89 |
Mean values from 0 to 100. A score of 100 indicates optimal function or maximum symptom intensity (ie, for functional measures, an increase indicates improvement, while for symptoms, an increase indicates worsening).
EORTC QLQ-C30, European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30.