Table 7.
Fatty Acid Pattern (% of Total Fatty Acids) in Plasma Phospholipids Before and After Study Treatment: Intention-to-Treat Population
| Pretreatment |
Posttreatment |
Pa |
Pb |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Test Group (SMOFlipid) | n | Control Group | n | Test Group (SMOFlipid) | n | Control Group | Test vs Control | Test Group (SMOFlipid) | Control Group | |
| C18:1 n-9 (oleic acid) | 22 | 29.84 (4.66) | 23 | 28.04 (4.31) | 19 | 25.72 (2.87) | 20 | 19.48 (2.92)c | .043 | .009 | <.001 |
| C20:3 n-9 | 22 | 1.32 (0.76) | 23 | 1.35 (1.11) | 19 | 0.16 (0.30) | 20 | 0.05 (0.06)c | .987 | <.001 | <.001 |
| Total n-6 PUFA | 22 | 12.45 (6.49) | 23 | 12.34 (5.51) | 19 | 35.36 (4.54) | 20 | 48.08 (5.81)c | <.001 | <.001 | <.001 |
| C18:2 n-6 (LA) | 22 | 3.88 (2.82) | 23 | 3.73 (2.33) | 19 | 29.02 (4.92) | 20 | 41.78 (6.66)c | <.001 | <.001 | <.001 |
| C20:4 n-6 (AA) | 22 | 6.99 (4.17) | 23 | 7.02 (3.46) | 19 | 5.07 (1.17) | 20 | 5.30 (1.55) | .477 | .263 | .036 |
| Total n-3 PUFA | 22 | 1.96 (0.90) | 23 | 1.65 (0.71) | 19 | 4.44 (1.29) | 20 | 2.24 (0.41)c | <.001 | <.001 | .008 |
| C18:3 n-3 (α-LNA) | 22 | 0.03 (0.03) | 23 | 0.02 (0.02) | 19 | 0.24 (0.09) | 20 | 0.44 (0.20)c | <.001 | <.001 | <.001 |
| C20:5 n-3 (EPA) | 22 | 0.14 (0.08) | 23 | 0.13 (0.07) | 19 | 1.35 (0.64) | 20 | 0.13 (0.07)c | <.001 | <.001 | .898 |
| C22:6 n-3 (DHA) | 22 | 1.72 (0.79) | 23 | 1.44 (0.62) | 19 | 2.50 (0.70) | 20 | 1.50 (0.37)c | .002 | .001 | .609 |
| n-6/n-3 ratio | 22 | 6.67 (2.41) | 23 | 7.65 (2.10) | 19 | 8.50 (2.29) | 20 | 22.04 (4.37)c | <.001 | <.001 | <.001 |
Values presented as mean (SD). All comparisons of change from baseline (within and between groups) are based on patients with pairwise available data. AA, arachidonic acid; α-LNA, α-linolenic acid; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; LA, linoleic acid; PUFA, polyunsaturated fatty acid.
a
Between-groups comparison of change from baseline, Wilcoxon test.
b
Within-groups comparison (pre- vs posttreatment), Wilcoxon signed rank test.
c
Between-groups comparison on day 8, P < .05.