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Schematic representation of the PDGF/VEGF-dependent control of vascular remodeling in hypoxic dura mater of post OVX animals. Hypoxia-induced activation of PDGF/VEGF system in dura mater stroma and microvessels controls remodeling of destabilized microvessels, while the balance between PI3K and PLCγ activity downstream of PDGF/VEGF signaling serves as a molecular switch between microvessel regression and angiogenesis.
