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Anti-inflammatory effect of 0.5 and 1.5% bucladesine cream given (a) 3 h before administration of arachidonic acid [one-way ANOVA: F(2,27) = 7.062; P = 0.003] or given (b) twice, i.e., 7 and 3 h before administration of arachidonic acid [one-way ANOVA: F(2,27) = 3.695; P = 0.0382]. *P < 0.05, **P < 0.01 versus vehicle-treated mice (one-way ANOVA with Dunnett’s post hoc test)
