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Summary of functional analyses of patient Nef mutants. The bar graph demonstrates relative efficiencies of HLA-A*02 (black bars) and CD4 (open bars) downregulation by Nef from all 15 subjects in the study. Reference Nef strains are ΔNef and wild-type NL4-3, and relative efficiencies of ΔNef and NL4-3 are set at 0 and 1, respectively. Bars represent means±standard deviations of three to five independent measurements.
