Table 3.

Correlations among the molecular signatures

Correlation coefficient
Concordance (P value)
	p53 wt	70-Gene low	Luminal	Wound-quiescent	ROR-S low
HR+, HER2−	0.44	0.26	0.62	0.34	0.40
	0.72	0.63	0.81	0.68	0.71
	(<0.001)	(0.002)	(<0.001)	(<0.001)	(<0.001)
p53 wt	⇓	0.32	0.65	0.55	0.56
	⇒	0.59	0.83	0.73	0.74
		(<0.001)	(<0.001)	(<0.001)	(<0.001)
70-Gene low		⇓	0.33	0.41	0.54
		⇒	0.61	0.82	0.83
			(<0.001)	(<0.001)	(<0.001)
Luminal			⇓	0.40	0.55
			⇒	0.68	0.75
				(<0.001)	(<0.001)
Wound-quiescent				⇓	0.63
				⇒	0.86
					(<0.001)

HR hormone receptor, wt wild type, ROR-S risk of relapse score. Signatures are shown as dichotomies: HR+/HER2− vs. not, luminal (A and B) vs. the other intrinsic subtypes (HER2 enriched, basal, and normal-like), p53 wild type vs. mutation, 70-gene prognosis low vs. high (only 13 (9%) patients are in the low risk prognosis group), and wound-quiescent vs. wound-activated. Concordance refers to the lower risk subsets