TABLE 5.
Cox Regression With Multiple Predictor Variables Including Ion Channel Dysfunction for First Cardiac Events
Variable | Hazard Ratio | 95% CI | P |
---|---|---|---|
Netherlands:United States | 2.78 | 1.48–5.23 | <0.01 |
Japan:United States | 1.63 | 1.02–2.63 | 0.04 |
Male <13 y:female <13 y | 1.94 | 1.29–2.91 | <0.01 |
Female 13–40 y:male 13–40 y | 1.95 | 0.99–3.87 | 0.06 |
QTc 500–530 ms:QTc <500 ms | 1.88 | 1.18–2.99 | <0.01 |
QTc >530 ms:QTc <500 ms | 3.22 | 2.06–5.05 | <0.001 |
QTc missing*:QTc <500 ms | 2.07 | 1.29–3.33 | <0.01 |
Dominant-negative:haploinsufficiency | 2.26 | 1.56–3.25 | <0.001 |
Time-dependent β-blocker use | 0.21 | 0.09–0.48 | <0.001 |
The analysis involved 354 subjects with known or suspected ion channel dysfunction; 2 subjects were not included because of missing data about the date of their first cardiac event.
The QTc missing category involves 26 patients who died suddenly at a young age without a prior ECG.