TABLE 2.

Summary of Current Density and Gating Parameters

	SCN5A	SCN5A + WT-β4	SCN5A + L179F-β4
INa density
pA/pF	−425.70±25.58 (n=5)	−378.43±61.81 (n=7)	−341.56±35.30 (n=8)
Activation
V1/2, mV	−43.78±1.28 (n=5)	−43.69±1.61 (n=7)	−43.37±1.13 (n=8)
Slope factor	3.12±0.10 (n=5)	3.63±0.16* (n=7)	3.85±0.23* (n=8)
Inactivation
V1/2, mV	−78.77±1.11 (n=10)	−82.28±0.74* (n=9)	−79.10±0.59† (n=9)
Slope factor	4.72±0.09 (n=10)	6.03±0.23* (n=9)	6.03±0.35* (n=9)
Recovery from inactivation
τ Fast, ms	1.52±0.14 (n=12)	1.48±0.10 (n=18)	1.80±0.18 (n=22)
Amp fast, %	0.83±0.02 (n=12)	0.82±0.02 (n=18)	0.75±0.02*† (n=22)
τ Slow, ms	37.28±3.93 (n=12)	24.50±4.01* (n=18)	47.95±7.51† (n=22)
Amp slow, %	0.18±0.01 (n=12)	0.19±0.01 (n=18)	0.20±0.01 (n=22)
Decay, −20 mV
τ Fast, ms	0.68±0.02 (n=5)	0.77±0.04 (n=6)	0.80±0.04 (n=8)
τ Slow, ms	2.85±0.26 (n=5)	3.16±0.31 (n=6)	3.66±0.27 (n=8)

All data are represented as mean±SD. INa indicates robust sodium current.

^*P<0.05 vs SCN5A.

^†P<0.05 vs WT-β4.