Table 4.
Prediction of granzyme B cleavage of CHIKV proteome
| Protein | Biological activity and function | Cleavage sites* |
|---|---|---|
| NSP1 | Non-structural: mRNA capping | 9, 11, 58, 525 |
| NSP2 | Non-structural: NTPase, helicase and protease activities | 116, 247, 343 |
| NSP3 | Non-structural: ADP-ribose phosphatase activity | 181, 350, 363, 506 |
| NSP4 | Non-structural: RNA polymerase activity | 219, 371, 476, 540 |
| E1 | Structural: virus-host cell fusion | Nil |
| E2 | Structural: virus-host cell attachment | 77 |
| E3 | Structural: unknown | Nil |
| Capsid | Structural: protease, viral nucleocapsid formation | 112, 174 |
| 6K | Structural: membrane permeabilization, budding of viral particles | Nil |
*Position of the P1 residue on the substrate. All predicted cleavage sites contain Asp at P1. Underlines indicate P1 location in the functional domain(s) of protein.