Figure 4.

Co-expression correlation and stability landscape for interactions between ordered and disordered proteins. Frequency of interactions in the context of co-expression correlation and stability of the interacting proteins, where a) both proteins are ordered and contain less than 30% disordered residues, b) one protein is disordered with more than 30% disordered residues, while the other is ordered, and c) both proteins are disordered and contain more than 30% disordered residues. Lighter colors indicate greater prevalence and gray indicates an absence of interactions within that range of co-expression correlation and stability. Refer Figure S4 in Additional File 1 for standard error values for all heat maps. The 3 types of interactions show distinct patterns highlighting the differences in the expression patterns of the genes encoding these proteins.