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Role of the antioxidant response element and the transcription factor Nrf2 in chemoprevention. ARE, antioxidant response element; Keap1, Kelch-like ECH associated protein 1, where ECH is chicken Nrf2; Nrf2, NF-E2 related factor; ERK2, extracellular regulated kinase 2, a component of the MAP kinase pathway postulated to regulate Nrf2; MRP, multidrug resistance related protein; MAF, small Maf proteins (MafK).
