Table 1.

Transcription factors mediating the regulation of cytoprotective genes

Factor	Induced enzymes
Ah receptor	CYP1A, CYP1B, GSTA, NQO1, UGT
PXR	CYP3A
PPAR α	CYP4A, UGTs
CAR	CYP2B, CYP2C, GSTA, GSTM
Nrf2/Nrf1	GST, HO-1, NQO1, GCS
AP1	NQO1, GSTP1

CYP, cytochrome P450—numbers and letters represent family and subfamily, respectively; GST, glutathione S-transferase—letters represent family; HO-1, hemeoxygenase 1; NQO1, quinone reductase; UGT, glucuronyl transferase; GCS, gamma glutamyl cysteine synthase.