Table 4.
Allelic frequency and genotypic distribution of the rs11536889 in the TLR4 gene in emphysema and control groups
| rs11536889 | Type | Emphysema (N = 106) |
Controls (N = 137) |
O.R. | P | Pa |
|---|---|---|---|---|---|---|
| Allelic frequency, n (%) | G | 136(64.2) | 206 (75.2) | 0.59 | 0.0083 | |
| C | 76 (35.8) | 68 (24.8) | 1.69* | |||
| Genotypic distribution, n (%) | GG | 48 (45.3) | 79 (57.7) | 0.61 | 0.055 | |
| GC | 40 (37.7) | 48 (35.0) | 1.12 | 0.664 | 0.034 | |
| CC | 18 (17.0) | 10 (7.3) | 2.60‡ | 0.019 |
N number of subjects. n number of present alleles or genotypes correspondingly
P and Pa values were calculated with χ2 tests of 2 × 2 and 3 × 2 contingency tables, respectively
*Odds Ratio = 1.69, 95% Confidence Intervals = 1.14-2.50
‡Odds Ratio = 2.60, 95% Confidence Intervals = 1.17-5.78