Table 5.

The four most common haplotypes were comprised of the seven SNPs in the TLR4 gene.

SNPs	Haplotypes*
	1	2	3	4
rs10759930	T	T	C	C
rs1927914	A	A	G	G
rs12377632	C	C	T	T
rs2149356	G	G	T	T
rs11536889	C	G	G	G
rs7037117	A	A	G	A
rs7045953	A	A	A	A
Freq. in emphysema	0.336	0.301	0.142	0.100
Freq. in control smokers	0.219	0.386	0.123	0.165
p†(emphysema vs. controls)	0.004‡	0.051	0.538	0.039#

The observed frequencies are shown for patients with the emphysema phenotype and control smokers

Abbreviations: A adenine; C cytosine; Freq. frequency; G guanine; SNPs single nucleotide polymorphisms; T thymine; TLR4 Toll-like receptor 4

*The designation of haplotype structure is given in Arabic numerals

^† By chi-square test

^‡Odds Ratio = 1.80, 95% Confidence Intervals = 1.21- 2.70

^# Odds Ratio = 0.56, 95% Confidence Intervals = 0.33- 0.97