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. Author manuscript; available in PMC: 2013 Feb 7.
Published in final edited form as: J Am Coll Cardiol. 2012 Feb 7;59(6):616–626. doi: 10.1016/j.jacc.2011.10.881

Figure 1.

Figure 1

Diagram of the efficacy of OxLDL targeted Mn micelles in the vascular phase. Mn is chelated to DTPA. Mn is released with the endosomes/lysosomes after uptake into intraplaque macrophage/foam cells (black circle). Due to intracellular release of Mn and subsequent interaction with intracellular components the MR signal is greatly enhanced. The r1 values are derived from Table 2.