Table 1.
Effects of calcineurin inhibition on cardiac hypertrophy
| Model | Species | Outcome | Ref. |
|---|---|---|---|
| Renovascular hypertension (2 kidney, 1 clip) | Mice | Prevention | 8 |
| Tropomodulin overexpression | Mice (transgenic) | Prevention | 9 |
| Myosin light chain-2 | Mice (transgenic) | Prevention | 9 |
| Fetal β tropomyosin | Mice (transgenic) | Prevention | 9 |
| Activated calcineurin | Mice (transgenic) | Prevention | 3 |
| Activated NFAT3 | Mice (transgenic) | Prevention | 3 |
| Pressure overload (abdominal aorta) | Rat | Prevention | 10 |
| Pressure overload (aortic banding) | Mice | Attenuated LVH, heart failure | 11 |
| Retinoic acid receptor | Mice (transgenic) | No prevention of hypertrophy | 9 |
| Pressure overload (aortic banding) | Mice | No prevention of hypertrophy | 12 |
| Pressure overload (aortic banding) | Rat | No prevention of hypertrophy | 13 |
| Pressure overload (aortic banding) | Rat | Attenuated LVH, death | 9 |
LVH, left ventricular hypertrophy.