Table 1.
Antigen | T cell | CD1 specificity |
---|---|---|
Microbial glycolipids | ||
Undefined microbial lipid | αβ T cells | CD1a |
Glucose monomycolate | αβ T cells | CD1b |
Lipoarabinomannan | αβ T cells | CD1b |
Phosphatidyl inositols | αβ T cells | CD1b |
Hexosyl-1-phosphoisoprenoids | αβ T cells | CD1c |
Autologous glycolipids | ||
Undefined autologous | αβ T cells | CD1a |
Brain lipids/gangliosides/sulfatide | αβ T cells | CD1b |
Undefined autologous | αβ and γδ T cells | CD1c |
Undefined autologous | NK (?) T cells* | CD1d |
Synthetic | ||
αGalCer | NK T cells† | CD1d |
Have diverse TCRs, may or may not express NK1.1.
Mostly NK1.1-positive cells with an invariant TCR α-chain.