Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1977 Mar;59(3):379–385. doi: 10.1172/JCI108650

Immunohistochemical changes in morphologically involved and uninvolved colonic mucosa of patients with idiopathic proctitis.

K M Das, W F Erber, A Rubinstein
PMCID: PMC333372  PMID: 320226

Abstract

Alterations in secretory component, IgA, IgG, and IgM were studied by immunofluorescent techniques in mucosal biopsy specimens obtained at colonoscopy from inflamed and grossly uninvolved colonic mucosa from 12 patients with idiopathic proctitis. Parotid-salivary secretory component and IgA and serum immunoglobulins were also investigated. Decreased secretory IgA was observed in the epithelium of all grossly involved rectal mucosa and in 40% of proximal normal mucosa. Salivary secretory IgA was not diminished. These observations suggest that a local immune defect may be pathogenetically related to idiopathic proctitis.

Full text

PDF
379

Images in this article

381Image
on p.381
381Image
on p.381
382Image
on p.382
382Image
on p.382

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bendixen G. Cellular hypersensitivity to components of intestinal mucosa in ulcerative colitis and Crohn's disease. Gut. 1969 Aug;10(8):631–636. doi: 10.1136/gut.10.8.631. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brandtzaeg P., Baklien K., Fausa O., Hoel P. S. Immunohistochemical characterization of local immunoglobulin formation in ulcerative colitis. Gastroenterology. 1974 Jun;66(6):1123–1136. [PubMed] [Google Scholar]
  3. Brandtzaeg P. Human secretory component. I. Purification of free secretory component from colostrum. Scand J Immunol. 1974;3(5):579–588. doi: 10.1111/j.1365-3083.1974.tb01291.x. [DOI] [PubMed] [Google Scholar]
  4. Brandtzaeg P. Mucosal and glandular distribution of immunoglobulin components: differential localization of free and bound SC in secretory epithelial cells. J Immunol. 1974 Apr;112(4):1553–1559. [PubMed] [Google Scholar]
  5. Broom B. C., de la Concha E. G., Webster A. D., Loewi G., Asherson G. L. Dichotomy between immunoglobulin synthesis by cells in gut and blood of patients with hypogammaglobulinaemia. Lancet. 1975 Aug 9;2(7928):253–256. doi: 10.1016/s0140-6736(75)90965-4. [DOI] [PubMed] [Google Scholar]
  6. Bürgi H. Endogenic defense against infectious disease in chronic bronchitis. Respiration. 1971;28(5):480–484. doi: 10.1159/000192833. [DOI] [PubMed] [Google Scholar]
  7. Cambier J. C., Butler J. E. Two immunochemically and physicochemically distinct secretory components from rat exocrine secretion. J Immunol. 1976 Apr;116(4):994–999. [PubMed] [Google Scholar]
  8. Crabbé P. A., Heremans J. F. The distribution of immunoglobulin-containing cells along the human gastrointestinal tract. Gastroenterology. 1966 Sep;51(3):305–316. [PubMed] [Google Scholar]
  9. Fubara E. S., Freter R. Protection against enteric bacterial infection by secretory IgA antibodies. J Immunol. 1973 Aug;111(2):395–403. [PubMed] [Google Scholar]
  10. Gelzayd E. A., Kraft S. C., Fitch F. W., Kirsner J. B. Distribution of immunoglobulins in human rectal mucosa. II. Ulcerative colitis and abnormal mucosal control subjects. Gastroenterology. 1968 Mar;54(3):341–347. [PubMed] [Google Scholar]
  11. Goodman M. J., Skinner J. M., Truelove S. C. Abnormalities in the apparently normal bowel mucosa in Crohn's disease. Lancet. 1976 Feb 7;1(7954):275–278. doi: 10.1016/s0140-6736(76)91404-5. [DOI] [PubMed] [Google Scholar]
  12. Green F. H., Fox H. The distribution of mucosal antibodies in the bowel of patients with Crohn's disease. Gut. 1975 Feb;16(2):125–131. doi: 10.1136/gut.16.2.125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kraft S. C., Kirsner J. B. Immunological apparatus of the gut and inflammatory bowel disease. Gastroenterology. 1971 May;60(5):922–951. [PubMed] [Google Scholar]
  14. LENNARD-JONES J. E., COOPER G. W., NEWELL A. C., WILSON C. W., JONES F. A. Observations on idiopathic proctitis. Gut. 1962 Sep;3:201–206. doi: 10.1136/gut.3.3.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  16. Perlmann P., Hammarström S., Lagercrantz R., Campbell D. Autoantibodies to colon in rats and human ulcerative colitis: cross reactivity with Escherichia coli O:14 antigen. Proc Soc Exp Biol Med. 1967 Jul;125(3):975–980. doi: 10.3181/00379727-125-32253. [DOI] [PubMed] [Google Scholar]
  17. Rubinstein A., Rádl J., Cottier H., Rossi E., Gugler E. Unusual combined immunodeficiency syndrome exhibiting kappa-IgD paraproteinemia, residual gutimmunity and graft-versus-host reaction after plasma infusion. Acta Paediatr Scand. 1973 Jul;62(4):365–372. doi: 10.1111/j.1651-2227.1973.tb08121.x. [DOI] [PubMed] [Google Scholar]
  18. Schachter H., Kirsner J. B. Definitions of inflammatory bowel disease of unknown etiology. Gastroenterology. 1975 Mar;68(3):591–600. [PubMed] [Google Scholar]
  19. Skinner J. M., Whitehead R. The plasma cells in inflammatory disease of the colon: a quantitative study. J Clin Pathol. 1974 Aug;27(8):643–646. doi: 10.1136/jcp.27.8.643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Sparberg M., Fennessy J., Kirsner J. B. Ulcerative proctitis and mild ulcerative colitis: A study of 220 patients. Medicine (Baltimore) 1966 Sep;45(5):391–412. doi: 10.1097/00005792-196609000-00003. [DOI] [PubMed] [Google Scholar]
  21. Strickland R. G., Korsmeyer S., Soltis R. D., Wilson I. D., Williams R. C., Jr Peripheral blood T and B cells in chronic inflammatory bowel disease. Gastroenterology. 1974 Oct;67(4):569–577. [PubMed] [Google Scholar]
  22. Strober W., Krakauer R., Klaeveman H. L., Reynolds H. Y., Nelson D. L. Secretory component deficiency. A disorder of the IgA immune system. N Engl J Med. 1976 Feb 12;294(7):351–356. doi: 10.1056/NEJM197602122940701. [DOI] [PubMed] [Google Scholar]
  23. Söltoft J., Binder V., Gudmand-Höyer E. Intestinal immunoglobulins in ulcerative colitis. Scand J Gastroenterol. 1973;8(4):293–300. [PubMed] [Google Scholar]
  24. Taub R. N., Sachar D., Janowitz H., Siltzbach L. E. Induction of granulomas in mice by inoculation of tissue homogenates from patients with inflammatory bowel disease and sarcoidosis. Ann N Y Acad Sci. 1976;278:560–564. doi: 10.1111/j.1749-6632.1976.tb47070.x. [DOI] [PubMed] [Google Scholar]
  25. Walker W. A., Isselbacher K. J., Bloch K. J. Intestinal uptake of macromolecules: effect of oral immunization. Science. 1972 Aug 18;177(4049):608–610. doi: 10.1126/science.177.4049.608. [DOI] [PubMed] [Google Scholar]
  26. Williams R. C., Gibbons R. J. Inhibition of bacterial adherence by secretory immunoglobulin A: a mechanism of antigen disposal. Science. 1972 Aug 25;177(4050):697–699. doi: 10.1126/science.177.4050.697. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES