Table 4.
Crude and adjusted geometric mean sex steroid hormone and growth factor concentrations in venous umbilical cord blood by race, females HUB Study 2004 to 2005
| AA | W | ||||
|---|---|---|---|---|---|
| Geometric mean |
95% CI | Geometric mean |
95% CI | P | |
| (A) Crude | |||||
| Testosterone (ng/mL) | 1.72 | 1.58, 1.86 | 1.62 | 1.46, 1.81 | 0.44 |
| DHEAS (ng/mL) | 367.5 | 332.6, 406.1 | 375.7 | 328.0, 430.5 | 0.80 |
| Estradiol (pg/mL) | 5,766 | 4,906, 6,777 | 6,452 | 5,195, 8,014 | 0.42 |
| SHBG (nmol/L) | 14.5 | 12.5, 17.0 | 17.6 | 14.2, 21.7 | 0.10 |
| IGF-1 (ng/mL) | 94.2 | 83.5, 106.2 | 123.3 | 104.6, 145.4 | 0.01 |
| IGF-2 (ng/mL) | 492.2 | 473.1, 512.2 | 549.5 | 520.5, 580.3 | 0.002 |
| IGFBP-3 (ng/mL) | 1,812 | 1,722, 1,907 | 2,065 | 1,926, 2,215 | 0.004 |
| Molar ratios of | |||||
| Testosterone/SHBG (×103) | 0.41 | 0.35, 0.48 | 0.32 | 0.25, 0.40 | 0.06 |
| Estradiol/SHBG | 1.45 | 1.14, 1.83 | 1.36 | 0.99, 1.86 | 0.75 |
| IGF-1/IGFBP-3 | 0.19 | 0.17, 0.21 | 0.22 | 0.19, 0.24 | 0.08 |
| IGF-2/IGFBP-3 | 0.98 | 0.94, 1.02 | 0.96 | 0.90, 1.02 | 0.59 |
| (B) Adjusted* | |||||
| Testosterone (ng/mL) | 1.79 | 1.64, 1.95 | 1.49 | 1.32, 1.69 | 0.02 |
| DHEAS (ng/mL) | 364.8 | 325.5, 408.9 | 375.9 | 319.2, 442.7 | 0.77 |
| Estradiol (pg/mL) | 5,813 | 4,906, 6,889 | 6,093 | 4,801, 7,731 | 0.75 |
| SHBG (nmol/L) | 14.7 | 12.4, 17.4 | 17.4 | 13.6, 22.4 | 0.27 |
| IGF-1 (ng/mL) | 97.2 | 85.6, 110.5 | 115.6 | 96.1, 138.9 | 0.14 |
| IGF-2 (ng/mL) | 496.5 | 475.5, 518.4 | 539.2 | 506.6, 573.9 | 0.04 |
| IGFBP-3 (ng/mL) | 1,854 | 1753, 1961 | 1,984 | 1829, 2151 | 0.18 |
| Molar ratios of | |||||
| Testosterone/SHBG (×103) | 0.42 | 0.35, 0.51 | 0.3 | 0.23, 0.39 | 0.03 |
| Estradiol/SHBG | 1.44 | 1.12, 1.85 | 1.29 | 0.91, 1.83 | 0.62 |
| IGF-1/IGFBP-3 | 0.19 | 0.17, 0.21 | 0.21 | 0.18, 0.24 | 0.23 |
| IGF-2/IGFBP-3 | 0.97 | 0.92, 1.02 | 0.98 | 0.91, 1.05 | 0.74 |
| (C) Mutually adjusted** | |||||
| Testosterone (ng/mL) | 1.82 | 1.67, 1.98 | 1.47 | 1.31, 1.66 | 0.006 |
| Estradiol (pg/mL) | 5,550 | 4,706, 6,545 | 6,608 | 5,233, 8,345 | 0.23 |
| SHBG (nmol/L) | 102.5 | 12.1, 17.4 | 17.9 | 13.8, 23.1 | 0.20 |
| IGF-1 (ng/mL) | 502.8 | 93.8, 111.9 | 105.0 | 92.3, 119.3 | 0.76 |
| IGF-2 (ng/mL) | 502.8 | 485.3, 520.9 | 527.0 | 500.6, 554.7 | 0.14 |
| IGFBP-3 (ng/mL) | 1,898 | 1,825, 1,975 | 1,900 | 1,794, 2,011 | 0.98 |
*
Adjusted for birth weight, placental weight, mother’s age and parity, and time of day of birth
**
Additionally, testosterone, estradiol and SHBG were mutually adjusted as were IGF-1, IGF-2, and IGFBP-3