Table 1.

Pharmacokinetic parameters determined in vivo by Lammerts van Bueren et al. [16]

Name	Definition	Value	Unit
V pla	Plasma volume	70	ml/kg
V int	Interstitial volume	35	ml/kg
k pi	Rate constant of plasma-interstitial transport	0.043	1/h
k ip	Rate constant of interstitial-plasma transport	0.043	1/h
kb	Constant thatensures quasi-steady state conditions	0.069	1/h
B max,PK	Whole-body capacity	2	mg/h/kg
K M,PK	Half-maximal binding capacity in vivo		mg/ml
kel	Elimination of EGFR by internalization and degradation	0.0055	1/h
q pi	Plasma-interstitial transport		ml/h
q ip	Interstitial-plasma transport		ml/h
CLlin	Target-independent drug clearance		ml/h/kg

Units were converted from mg to nmol using the scaling factor with MW_{mAbs = 148000 g/mol, i.e., 1mg = nmol