Table 1.

Main receptors on NK cells involved in anti-tumor immune response

Function	Receptors	Ligands	Species	Ref
Inhibition	KIR (long cytoplasmic tail)	HLA-A,B,C allotypes	H	42,43
	Ly49A/C	MHC class I	M	44,45
	CD94-NKG2A	MHC-E	H, M	48,50
Activation	CD16	IgG	H, M
		HPV	H	61
	NKG2D	MICA/B-RAET	H
		RAET-H60	M
	NKp30	B7-H6, Heparan sulfate	H	75–78
	NKp44	Heparan sulfate	H	76
	NKp46	Heparan sulfate, unknown tumor ligands	H, M	75,76,121

Abbreviations: HLA, human leucocyte antigen; H, Human; Ig, immunoglobulin; M, mouse; MHC, major histocompatibility complex; MICA/B, major histocompatibility complex class I-related; RAET, retinoic acid early transcript.