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. 2011 Dec 29;40(8):3484–3495. doi: 10.1093/nar/gkr1245

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Endogenous PNKP colocalizes with mitochondrial markers. (A) Immunofluorescence of PNKP in A549 cells. PNKP localizes to mitochondria (in addition to the nuclei) as demonstrated by colocalization with the mitochondrial markers mitofilin and COX IV. (B) The shRNA KD of PNKP (lower panel) results in a decrease of the fluorescence signal for PNKP in both nuclei and mitochondria of A549 cells compared to the control cell line carrying scrambled shRNA (upper pannel).