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. 2011 Dec 23;40(8):3316–3328. doi: 10.1093/nar/gkr1247

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Comparison of models of StpA and H-NS DNA-binding mechanism. In low magnesium buffer conditions, StpA (orange circles) forms a rigid filament along DNA, which is able to interact with another naked DNA segment to mediate DNA bridging. The rigid filament on the DNA is unable to interact with another bound StpA filament. H-NS (blue circles) in low magnesium buffer is also able to form a rigid filament along DNA but unlike the StpA filament, the bound filament is unable to interact with another naked DNA segments (16). StpA in the presence of high magnesium buffer conditions causes inter-co-filament-mediated higher order DNA compaction. Unlike the StpA filament, formation of H-NS filament is suppressed in high magnesium concentrations. In addition, DNA bridging will occur in high magnesium concentrations (16). Blue circles and squares represent possible different H-NS-binding species in low and high magnesium conditions where two distinct binding modes were reported (16).