Table 3.
Frequencies of DRB1 and DQB1 alleles in RF and RHD patients compared with control subjects
| Group (n = 140) | DRB1*06 | DRB1*07 | DQB1*0302 | DQB1*0401-2 | |
| All RF (n = 140) | gf(P) + OR/χ2 | (0.0023) 0.18/11.96 | (0.01) 4.18/6.68 | (0.001) 3.13/10.67 | (0.015) 4.33/11.79 |
| MVR (n = 48) | gf(P) + OR/χ2 | 0.15 | (0.03) 4.45/4.95 | 1.09 | (0.001) 8.20/21.59 |
| MVL (n = 40) | gf(P) + OR/χ2 | 0.18 | (0.01) 5.44/6.59 | (0.001) 4.18/10.21 | 1.25 |
| Sydenham's chorea (n = 16) | gf(P) + OR/χ2 | 0 | (0.002)11.31/13.19 | 1.79 | (0.005) 6.36/7.17 |
| without RHD (n = 46) | gf(P) + OR/χ2 | 0.31 | (0.001) 7.35/11.65 | (0.005) 3.50/7.81 | (0.01) 4.14/6.78 |
| Control subjects (n = 200) | gf | 0.14 | 0.02 | 0.07 | 0.04 |
Boldface type highlights statistically significant associations for patients vs controls. gf (gene frequency) P (probability), OR (odds ratio), and Mantel-Hanszel values (χ2) are reported only for significant associations (P < 0.05). n = number of haplotypes (e.g. 140 haplotypes from 70 individuals). The nature of valve lesions was not reported for two patients. MVL, multivalvular lesions; MVR, mitral valve regurgitation; RF, rheumatic fever; RHD, rheumatic heart disease.