Table 2.

Echocardiographic analysis

	Mfn-1 WT (n = 11)	Mfn-1 KO (n = 13)
Age, day	125 ± 11	129 ± 11
BW, g	36.3 ± 5.3	34.7 ± 3.8
Cardiac mass, mg	165.7 ± 14.9	167.58 ± 16.0
CM/BW, mg/g	4.63 ± 0.62	4.86 ± 0.55
EDV, μl	76.11 ± 15.6	84.23 ± 18.15
ESV, μl	32.43 ± 9.25	38.32 ± 15.96
EF, %	57.47 ± 6.90	56.28 ± 9.39
CO, ml/min	22.53 ± 4.70	22.79 ± 3.59
FS, %	56.65 ± 9.19	55.23 ± 11.80
PAF, mm/s	1252 ± 213	1403 ± 315
PPF, mm/s	842 ± 136	820 ± 123
E, mm/s	583 ± 126	513 ± 101
A, mm/s	447 ± 95	420 ± 86
ET, ms	49.50 ± 5.33	45.14 ± 4.35
E', mm/s	11.89 ± 2.41	11.36 ± 2.29
A', mm/s	11.56 ± 1.02	11.57 ± 1.10

Results are means ± SD. For derivation of the different parameters please refer to materials and methods. Comparisons for statistical significance were performed with two-tailed Student's t-test.

BW, body weight; CM, cardiac mass; EDV, end-diastolic volume; ESV, end-systolic volume; EF, ejection fraction; CO, cardiac output; FS, fractional shortening; PAF, peak aortic flow; PPF, peak pulmonic flow; E, early mitral inflow; A, late mitral inflow; ET, ejection time; E', early relaxation velocity at the mitral annulus; A', late relaxation velocity at the mitral annulus.