Fig. 4.

Determination of carotid artery stiffness in control and diabetic mice of WT, AI^+/+, and AI^+/− genotypes. Stiffness was assessed as a change in circumferential wall strain per unit change in circumferential wall stress as hydrostatic pressure was incrementally increased in vessels. Curves of this relationship are shown for WT (A), AI^+/+ (B), and AI^+/− (C) mice that were either control nondiabetic (filled symbols) or diabetic (open symbols). The slopes of these relationship (β-coefficient) are shown in the adjacent histogram. n = 5 mice/group. *P < 0.05 vs. the control group of a given genotype.