Table 1. Demographic, atopy, and exposures study characteristics for cases of wheezing and controls.
Cases were defined as medically attended wheezing ≤ 42 days after vaccination.
| Cases who wheezed (n=6) | Controls who did not wheeze (n=75) | p-valuea | |
|---|---|---|---|
| Mean age – mo. | 19.0 | 23.8 | 0.26 |
| Sex – no. (%) Male Female |
4 (66.7%) 2 (33.3%) |
39 (52.0%) 36 (48.0%) |
0.68 |
| Race – no. (%) European-American African-American Mixed |
6 (100%) 0 0 |
71 (94.7%) 2 (2.7%) 2 (2.7%) |
1.00 |
| Season bornb - no. (%) Spring Summer Fall Winter |
0 1 (16.7%) 3 (50.0%) 2 (33.3%) |
27 (36.0%) 20 (26.7%) 13 (17.3%) 15 (20.0%) |
0.058 |
| No. of children in home – no. (%) One Two ≥Three |
0 3 (50%) 3 (50%) |
5 (6.9%) 31 (42.5%) 37 (50.7%) |
1.00 |
| Born premature (<36 wks) – no. (%) | 0 | 9 (12.2%) | 1.00 |
| Breastfeed – no. (%) | 5 (83.3%) | 56 (74.7%) | 1.00 |
| Live in home with pet(s)a – no. (%) | 3 (75.0%) | 33 (58.9%) | 0.64 |
| Live in home with smoker(s) – no. (%) | 0 | 6 (8.1%) | 1.00 |
| Patient or sibling attends daycare – no. (%) | 4 (57.1%) | 64 (84.2%) | 0.11 |
| Personal history of asthma/wheezing – no. (%) | 5 (71.4%) | 28 (37.3%) | 0.11 |
| Personal history of atopy – no. (%) | 2 (33.3%) | 22 (29.3%) | 1.00 |
| Maternal history of asthma/wheezing – no. (%)c | 0 | 16 (21.9%) | 0.34 |
| Maternal history of atopy – no. (%)c | 3 (50%) | 46 (63.0%) | 0.67 |
| 1st degree relative history of asthma/wheezing – no. (%)c | 6 (100%) | 20 (27.4%) | 0.001 |
| 1st degree relative history atopy – no. (%)c | 6 (100%) | 48 (65.8%) | 0.17 |
| 2nd degree relative history of asthma/wheezing – no. (%)c | 3 (50%) | 20 (27.4%) | 0.35 |
| 2nd degree relative history atopy – no. (%)c | 3 (50%) | 36 (49.3%) | 1.00 |
| Received CAIV-T vaccine | 5 (71.4%) | 31 (44.3%) | 0.24 |
a
Fisher’s exact test or t-test
b
Spring = March, April, May; Summer = June, July, August; Fall = September, October, November; Winter = December, January, February
c
2 adopted children were removed before analysis.