Table 2. SNPs associated with medically attended wheezing after influenza vaccination.
Cases were defined as medically diagnosed wheezing ≤ 42 days after vaccine. SNPs associated at p<9.5×10−5 for six cases and 55 controls are shown below.
| Chromoso me |
rs number |
Base position |
Allel es |
Frequency among cases |
Frequency among controls |
p- value |
Candidate gene (SNP type) |
|---|---|---|---|---|---|---|---|
| 1 | rs11265263 | 1.58E+08 | A/C | 0.58 | 0.04 | 3.34E-06 | |
| 19 | rs3745504 | 55463421 | G/A | 1.0 | 0.36 | 1.59E-05 |
MYH14 (synonymous) |
| 20 | rs4815682 | 4207113 | A/G | 1.0 | 0.36 | 1.59E-05 | |
| 4 | rs7677253 | 1.9E+08 | G/A | 0.50 | 0.036 | 4.00E-05 | |
| 19 | rs4801824 | 55448942 | G/A | 0.92 | 0.30 | 4.77E-05 |
MYH14 (intron) |
| 8 | rs11786594 | 69522698 | C/A | 0.75 | 0.16 | 5.30E-05 |
C8orf34 (intron) |
| 5 | rs249923 | 1.42E+08 | A/G | 1.0 | 0.42 | 6.87E-05 |
FGF1 (intron) |
| 10 | rs11196181 | 1.15E+08 | A/G | 0.42 | 0.02 | 7.24E-05 |
TCF7L2 (intron) |
| 6 | rs17571811 | 10443471 | G/A | 0.75 | 0.17 | 7.59E-05 | |
| 3 | rs4613440 | 14530815 | A/G | 0.92 | 0.32 | 8.11E-05 |
GRIP2 (synonymous) |
| 16 | rs12918720 | 17247437 | A/G | 0.92 | 0.32 | 8.11E-05 |
XYLT1 (intron) |