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. Author manuscript; available in PMC: 2012 Apr 25.
Published in final edited form as: Cell Rep. 2012 Feb 23;1(2):110–117. doi: 10.1016/j.celrep.2011.12.001

Figure 1.

Figure 1

SRSF1 expression correlates with MYC levels in human lung tumors and cell lines. (A) SRSF1 expression profile from microarray analysis of 132 lung tumors (expO). The data were normalized to Z-score and divided into two categories: tumors expressing high or low MYC levels. The dot plot shows the distribution and the median (horizontal line). Mann-Whitney test ***P<0.0001. (B) Immunoblotting of MYC and SRSF1 in lung-cancer cell lines and lung primary fibroblasts, showing significant correlation between the expression of the two oncoproteins (r=0.75, one-tailed t-test *P=0.05). (C) RT-PCR and (D) Immunoblotting of MYC and SRSF1 in NCI.H460 and NCI.H1666 cells transfected with control siRNA (luciferase) or one of two siRNAs against MYC. See also Figure S1.