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. 2012 Apr 23;7(4):e35684. doi: 10.1371/journal.pone.0035684

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Wu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Immune positivity of P-Smad2C was significantly decreased in cancer tissues (b) when compared with surrounding normal tissues (a) in 77 out of 130 patients with gastric cancer. Representative pictures were taken from a patient with signet-ring cell carcinoma. (B) In tumor tissues, cancer cells with poor atypia (e–h) showed decreased P-Smad2C staining compared to those with a well-differentiated phenotype (a–d).