Table 2.
Association of PAI-1 polymorphism with metabolic syndrome parameters among subjects
| Metabolic syndrome parameter | PAI-1 polymorphism |
|||||
|---|---|---|---|---|---|---|
| 5G/5G n (37) | 4G/5G n (63) | 4G/4G n (30) | Univariat p value | 4G/4G vs 5G/5G p value | 4G/5G vs 5G/5G p value | |
| Body mass index (kg/m2) | 21.3 (20.4–22.3) | 22.4 (21.7–23.2) | 23.2 (22.1–24.4) | 0.032 | 0.01 | 0.08 |
| Waist circumference (cm) | 77.1 (74.8–79.4) | 78.4 (76.7–80.3) | 78.0 (75.3–80.8) | 0.66 | 0.61 | 0.34 |
| Diastolic blood pressure (mmHg) | 77.5 (75.3–79.7) | 80.4 (78.7–82.2) | 81.2 (78.6–83.9) | 0.056 | 0.03 | 0.008 |
| Systolic blood pressure (mmHg) | 127 (123–132) | 129 (125–132) | 133 (128–138) | 0.23 | 0.096 | 0.62 |
| Triglyceride (mmol/l) | 0.92 (0.80–1.03) | 1.04 (0.95–1.14) | 1.17 (1.03–1.33) | 0.026 | 0.007 | 0.099 |
| T-cholesterol (mmol/l) | 4.97 (4.72–5.24) | 5.32 (5.11–5.54) | 5.21 (4.90–5.53) | 0.14 | 0.26 | 0.047 |
| HDL-cholesterol (mmol/l) | 1.62 (1.52–1.72) | 1.52 (1.46–1.59) | 1.51 (1.41–1.61) | 0.21 | 0.12 | 0.13 |
| LDL-cholesterol (mmol/l) | 2.90 (2.66–3.16) | 3.27 (3.07–3.49) | 3.00 (2.71–3.30) | 0.07 | 0.64 | 0.03 |
| Fasting blood sugar (mmol/l) | 5.01 (4.9–5.15) | 4.97 (4.87–5.08) | 4.93 (4.77–5.09 | 0.75 | 0.45 | 0.69 |
| Insulin (pmol/l) | 39.9 (34.3–46.4) | 43.7 (38.8–49.1) | 46.9 (39.3–55.8) | 0.38 | 0.17 | 0.35 |
| Insulin resistance | 0.78 (0.66–0.91) | 0.86 (0.76–0.96) | 0.89 (0.74–1.06) | 0.5 | 0.27 | 0.37 |
The result presented as geometric mean and 95% confidence interval of the mean adjusted for age, gender and race as covariates which evaluated by univariate (General Linear Model). Number of subjects = 130.