Table 3.
Association of tPA Polymorphism with metabolic syndrome parameters among subjects
| Metabolic syndrome parameter | tPA polymorphism |
|||||
|---|---|---|---|---|---|---|
| D/D n (36) | I/D n (63) | I/I n (30) | Univariate p value | I/I vs D/D p value | I/D vs D/D p value | |
| Body mass index (kg/m2) | 22.1 (21.1–23.2) | 22.4 (21.7–23.2) | 22.0 (21.0–23.0) | 0.76 | 0.84 | 0.65 |
| Waist circumference (cm) | 77.4 (75.0–79.8) | 77.9 (76.2–79.7) | 78.4 (76.0–80.9) | 0.83 | 0.45 | 0.72 |
| Diastolic blood pressure (mmHg) | 79.7 (77.3–82.2) | 79.0 (77.2–80.9) | 80.6 (78.0–83.3) | 0.63 | 0.61 | 0.68 |
| Systolic blood pressure (mmHg) | 133 (128–138) | 129 (126–132) | 128 (124–133) | 0.32 | 0.19 | 0.17 |
| Triglyceride (mmol/l) | 0.95 (0.83–1.08) | 1.04 (0.95–1.14) | 1.12 (0.98–1.27) | 0.2 | 0.07 | 0.25 |
| T-cholesterol (mmol/l) | 5.07 (4.81–5.34) | 5.30 (5.09–5.51) | 5.32 (5.00–5.66) | 0.35 | 0.9 | 0.19 |
| HDL-cholesterol (mmol/l) | 1.56 (1.46–1.66) | 1.54 (1.47–1.61) | 1.52 (1.42–1.63) | 0.86 | 0.59 | 0.69 |
| LDL-cholesterol (mmol/l) | 3.02 (2.77–3.28) | 3.18 (2.98–3.39) | 3.17 (2.87–3.50) | 0.58 | 0.43 | 0.32 |
| Fasting blood sugar (mmol/l) | 4.96 (4.82–5.10) | 4.98 (4.88–5.08) | 5.02 (4.87–5.17) | 0.84 | 0.55 | 0.8 |
| Insulin (pmol/l) | 39.5 (33.8–46.0) | 45.2 (40.2–50.7) | 42.2 (35.6–50.0) | 0.39 | 0.56 | 0.17 |
| Insulin resistance | 0.78 (0.66–0.92) | 0.89 (0.79–1.00) | 0.83 (0.69–0.98) | 0.45 | 0.66 | 0.22 |
The result presented as geometric mean and 95% confidence interval of the mean adjusted for age, gender and race as covariates which evaluated by univariate (General Linear Model). Number of subjects = 130.