Table 5.
Association of tPA polymorphisms with their plasma activities and antigens and tPA/PAI-1 complex among subjects
| Parameters | tPA polymorphism |
|||||
|---|---|---|---|---|---|---|
| D/D n (36) | I/D n (63) | I/I n (30) | Univariate p value | I/I vs D/D p value | I/D vs D/D p value | |
| PAI-1 activity (IU/ml) | 12.5 (10.3–15.1) | 14.7 (12.6–17.1) | 14.6 (11.7–18.3) | 0.33 | 0.26 | 0.16 |
| PAI-1 antigen (ng/ml) | 34.5 (29.3–40.4) | 32.3 (28.4–36.8) | 28.3 (23.9–33.6) | 0.25 | 0.11 | 0.57 |
| tPA activity (U/ml) | 2.60 (1.94–3.40) | 1.97 (1.54–2.46) | 3.03 (2.24–4.02) | 0.06 | 0.45 | 0.14 |
| tPA antigen (ng/ml) | 3.93 (3.11–4.92) | 3.74 (3.10–4.48) | 3.33 (2.54–4.28) | 0.5 | 0.3 | 0.96 |
| tPA/PAI-1 complex (ng/ml) | 2.44 (1.50–3.74) | 3.46 (2.50–4.67) | 1.59 (0.84–2.65) | 0.04 | 0.23 | 0.21 |
The result presented as geometric mean and 95% confidence interval of the mean adjusted for age, gender and race as covariates which evaluated by univariate (General Linear Model). Number of subjects = 130.