Table 3.
Age- and multivariable-adjusted odds ratios for restless legs syndrome according to migraine subtypes at baseline in the Women’s Health Study (n=31,370)
| Migraine subtype | Women with RLS % (n) |
Age-adjusted Model | Multivariable-adjusted Model* | ||
|---|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | ||
| No migraine (n=24,434)† |
11.2 (2,738) |
Ref | ----- | Ref | ----- |
| Migraine with aura (n=1,579) |
15.1 (239) |
1.42 (1.23–1.63) | <0.0001 | 1.27 (1.10–1.48) | 0.001 |
| Migraine without aura (n=2,418) |
14.5 (351) |
1.35 (1.20–1.52) | <0.0001 | 1.24 (1.09–1.40) | <0.001 |
| Prior migraine (n=1,725) |
13.4 (232) |
1.23 (1.07–1.42) | 0.005 | 1.11 (0.96–1.28) | 0.17 |
| New reports of migraine (n=1,135) |
15.3 (174) |
1.44 (1.22–1.70) | <0.0001 | 1.30 (1.10–1.54) | 0.003 |
RLS, restless legs syndrome; OR, odds ratio; CI, confidence interval.
adjusted for: age, BMI, history of diabetes, history of hypertension, history of elevated cholesterol, alcohol consumption, smoking, physical activity, parental history of myocardial infarction prior to age 60, major CVD, postmenopausal hormone use, menopausal status, history of depression, history of Parkinson’s disease, number of pregnancies lasting ≥6 months, iron supplementation use, fatigue, ethnicity, and geographic location.
79 women with missing information on migraine at baseline were included in the model as a separate “dummy” category.