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Granule cell dispersion and CA1 pyramidal cell loss following intrahippocampal KA administration. After KA-induced SE, granule cell dispersion was noted in both AQP4+/+ (A) and AQP4−/− (B) mice as early as post-SE day 7. Granule cell dispersion was observed at post-SE day 14 and 30, and is accompanied by loss of NeuN immunoreactivity in the CA1 pyramidal cell layer. Scale bar = 200μm.
