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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2012 Jan 25;18(5):683–689. doi: 10.1016/j.bbmt.2012.01.006

Figure 2. Immature vascular architecture and robust thymic reconstitution are lost during the first week of postnatal life.

Figure 2

(A) In vivo tomato lectin staining comparing vasculature between newborn (left panel) and adult (right panel) immune-competent (C57Bl/6) and immune- deficient (NOD/SCID/β2m−/−) mice. (B) VEGF-TRAP reduces vascular density of newborn thymi in immune-competent (C57Bl/6) and immune deficient (NSG) mice. Control mice were treated with hFC. (C, D) Effect of host age on bone marrow (C) and thymic reconstitution (D). NSG neonatal mice were transplanted with CD45.2+ BM without irradiation at Day 1, 4, 7 and 10 of life, (n = 4, 7, 7 and 9 mice respectively) and analyzed at 3 weeks post BMT. All numbers are mean ± standard error of the mean (SEM).