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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Anesth Analg. 2012 Mar 5;114(5):956–961. doi: 10.1213/ANE.0b013e31824c4eb5

Figure 2.

Figure 2

Note the significant changes (p < 0.05 at 2 hours vs control value at time 0) in blood cyanide (upper graph), serum lactate (middle graph) and arterial pH (lower graph) in all 8 pigs during sodium nitroprusside infusion (sulfanegen and placebo group). At the end of the two hour infusion, 4 pigs were treated with sulfanegen sodium (2.5 g IV) and the other 4 were given a similar volume of normal saline placebo. None of the placebo-treated pigs survived (placebo group). All the antidote-treated pigs survived with significant improvements (p < 0.05 at 5 hours vs control) in pH, cyanide and lactate levels (sulfanegen group). The surviving pigs received 2 additional doses of sulfanegen sodium (2.5 g IV) at hours 3 and 4.