Table 3.
Hemodynamic changes observed during cyanide (CN) infusion. (all values are mean±SD)
| Mean Arterial Blood Pressure | ||||||
|---|---|---|---|---|---|---|
| Group | Baseline | peak Cyanide toxicity value | Last value before death (no antidote group); 15 minutes after sulfanegen (sulfanegen group) | 60 minutes after sulfanegen | 120 minutes after sulfanegen | 180 minutes after sulfanegen |
| No antidote | 92±11 | 117±23 | *22±10 | N.A. | N.A. | N.A. |
| Sulfanegen Group | 91±10 | *122±18 | *71±25 | *75±16 | 81±13 | 87±9 |
| Heart Rate (beats/minute) | ||||||
| No antidote | 111+20 | *182±36 | *43±20 | N.A. | N.A. | N.A. |
| Sulfanegen Group | 118±31 | *149±38 | *155±29 | *152±13 | *154±32 | 143±29 |
| Mean Pulmonary Artery Pressure (mmHg) | ||||||
| No antidote | 15±0 | *19±1 | 7±2 | N.A. | N.A. | N.A. |
| Sulfanegen Group | 16±3 | *27±9 | 16±4 | 15±3 | 15±2 | 14±1 |
| CVP (mm Hg) | ||||||
| No antidote | 6±2 | *18±8 | 9±5 | N.A. | N.A. | N.A. |
| Sulfanegen Group | 4±1 | *12±7 | 6±5 | 6±5 | 5±2 | 6±3 |
*
p < 0.05 vs baseline
(The results shown are those obtained at baseline and during peak CN toxicity. The group of pigs that did not receive the antidote all died. The other group of pigs received the antidote sulfanegen sodium at peak CN toxicity. A second dose of sulfanegen sodium was administered after 60 minutes to surviving pigs in this group).