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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Atherosclerosis. 2012 Feb 3;222(1):135–137. doi: 10.1016/j.atherosclerosis.2012.01.028

Table 2.

Statistical Parameters for Coronary Heart Disease Risk Prediction with the addition of 9p21 allele, CIMT and plaque to traditional risk factors: The ARIC study

ACRS only ACRS+9p21
allele		 ACRS+
CIMT+plaque
(*)		 ACRS+CIMT+plaque
+ 9p21allele (*)
% reclassified (#) 8.9 (n=828) 24.7% (n=2305) 25.9% (n=2416)
G-B goodness of fit test (p value) 15.75 (p=0.07) 17.6 (p=0.04) 14.48 (p=0.11) 15.27 (p=0.08)
NRI (%) (#) −0.5 8.3 9.8
Clinical NRI (%) (#) 4.1 25.01 28.6
IDI (#) 0.002 0.013 0.016
(#)

Comparison of various models to the ARS only model

(*)

Comparison of ARS+CIMT+plaque+9p21 allele to ARS+CIMT+plaque: % reclassified 8.6% (n=803), NRI 1.5%, clinical NRI 6.2%, IDI 0.002,

G-B: Grønnesby Borgan test of model calibration; NRI: Net reclassification index; clinical NRI: NRI in the intermediate (5–20% risk groups); IDI: Integrated discrimination index