Table 2.
SNPs significantly associated with longevity after correction for multiple testing in the case-control comparison of middle-aged and oldest-old Danish cohorts. (A) Both genders combined and (B) additional SNP in sex-stratified analyses.
| (A) Both genders | Gene | SNP | Minor/Major allele | Chr./position | Position in gene | MAF MADT/1905 | PCCA uncorrected | PCCA corrected | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| Pro/antioxidants | GSR | rs1002149 | A/C | 8/30705280 | 5' | 0.183/0.137 | 1.47.10−4 | 0.0335 | 0.706 (0.589–0.845) |
| GH/IGF/INS | INS | rs3842755 | A/C | 11/2137372 | 3'UTR | 0.292/0.424 | 8.38.10−16 | 1.10−4 | 1.789 (1.552–2.063) |
| KL | rs1207362 | A/C | 13/32510839 | Intronic | 0.339/0.245 | 2.77.10−9 | 1.10−4 | 0.634 (0.545–0.737) | |
| GHRHR | rs2267723 | G/A | 7/30973467 | Intronic | 0.414/0.330 | 2.28.10−7 | 1.10−4 | 0.696 (0.607–0.799) | |
| GHSR | rs572169 | A/G | 3/173648421 | Coding (syn) | 0.342/0.274 | 1.65.10−5 | 0.0045 | 0.725 (0.626–0.839) | |
| IGF2R | rs9456497 | G/A | 6/160363418 | Intronic | 0.191/0.252 | 1.86.10−5 | 0.0050 | 1.424 (1.211–1.674) | |
| DNA repair | RAD52 | rs11571461 | G/A | 12/896580 | Intronic | 0.098/0.195 | 5.05.10−15 | 1.10−4 | 2.226 (1.815–2.730) |
| WRN | rs13251813 | A/G | 8/31083753 | Intronic | 0.077/0.134 | 1.72.10−7 | 2.10−4 | 1.840 (1.460–2.318) | |
| POLB | rs2953983 | G/A | 8/42332413 | Intronic | 0.080/0.123 | 4.54.10−5 | 0.0225 | 1.599 (1.274–2.006) | |
| RAD23B | rs1805329 | A/G | 9/109124149 | Coding (non-syn) | 0.245/0.190 | 6.74.10−5 | 0.0309 | 0.722 (0.615–0.847) | |
| (B) Males | Gene | SNP | Minor/Major allele | Chr./position | Position in gene | MAF MADT/1905 | PCCA uncorrected | PCCA corrected | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| DNA repair | NTLH1 | rs3211994 | A/G | 16/2029029 | 3' | 0.112/0.201 | 1.38.10−5 | 0.0056 | 1.994 (1.455–2.732) |
Notes: Chr: chromosome, MAF: minor allele frequency, MADT: the Study of Middle Aged Danish Twins, 1905: the Danish 1905 Birth cohort, PCCA: allelic case-control comparison P-value, OR: odds ratio, 95% CI: 95% confidence interval, UTR: untranslated region, Syn: synomonous, Non-syn: Non-synomonous.