Figure 4. The effect of SCN1Bb subunit on current decay of INa.
A: Overlapping sodium channel current (INa) traces from cells expressing NaV1.5, in the absence and presence of SCN1Bb wild-type (WT) and variant. INa was evoked by +20mV depolarizing pulses from a holding potential of −120m V. Traces are shown normalized to their individual peak value. B and C: Current decay (τ fand τs) for all 3 groups fitted with double exponential function.