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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Heart Rhythm. 2011 Dec 7;9(5):760–769. doi: 10.1016/j.hrthm.2011.12.006

Figure 5. Functional characterization of SCN1Bb/R214Q on INa.

Figure 5

A: Representative traces recorded from wild-type (WT) and mutant channels in response to the voltage clamp protocol depicted on right middle inset designed to assess steady-state inactivation. B and C: Voltage dependence of inactivation and activation of SCN5A/WT and co-transfection of either SCN1Bb/WT or SCN1Bb/R214Q. Averaged values and the number of cells used are represented in Online Table 3. D: Recovery from fast inactivation of 3 groups determined using the two-pulse protocol shown in the inset. Fitting to a double-exponential function yielded the time constants demonstrated in Online Table 3. τf and τs in SCN5A/WT + SCN1Bb/R214Q were significantly slower as compared with SCN5A/WT + SCN1Bb/WT.