Table 3.
Blood glucose, triacylglycerol, free fatty acid, and ketone body levels of fasted wild type (WT) and PDK4 knockout (PDK4 KO) mice fed a HSF diet with and without clofibric acid
| Genotype | Clofibric acid | Blood glucose |
Triacylglycerol | Free fatty acid |
Ketone bodies |
|---|---|---|---|---|---|
| mg/dl | mmole/l | ||||
| WT | − | 143 ± 5 | 48 ± 5 | 0.48 ± 0.10 | 0.20 ± 0.02 |
| WT | + | 134 ± 7 | 29 ± 1*† | 0.37 ± 0.07 | 0.58 ± 0.10* |
| PDK4 KO | − | 90 ± 9*# | 71 ± 9* | 0.67 ± 0.09 | 0.46 ± 0.05* |
| PDK4 KO | + | 105 ± 7 *# | 29 ± 1*† | 0.29 ± 0.05 † | 1.09 ± 0.14*†# |
Data are presented as mean ± S.E., n = 5 or 6 for wild type and PDK4 knockout mice fed on a HSF diet with and without clofibric acid.
P < 0.05 relative to non-treated wild type mice.
P < 0.05 relative to non-treated PDK4 knockout mice.
P < 0.05 relative to clofibric acid-treated wild type mice.