Table 5.

PDC activity in livers and gastrocnemius muscles of fasted wild type (WT) and PDK4 knockout (PDK4 KO) mice fed a HSF diet with and without clofibric acid

Genotype	Clofibric acid	Liver	Gastrocnemius
		% Active
WT	−	0.6 ± 0.2	1.6 ± 0.2
WT	+	7.6 ± 0.5*†	1.5 ± 0.6
PDK4 KO	−	3.1 ± 0.4*	2.3 ± 0.3
PDK4 KO	+	9.0 ± 1.5*†	1.9 ± 0.4

Data are presented as mean ± S.E., n = 5 or 6 for wild type and PDK4 knockout mice fed on a HSF diet with and without clofibric acid. % Active PDC was determined as described in the Materials and Methods section.

^*P < 0.03 relative to non-treated wild type mice.

^†P < 0.01 relative to non-treated PDK4 knockout mice.