Table 2.
Results of statistically significant tests
| Analysis | Results (number of patients and the % in the analysis) | p value | |||
|---|---|---|---|---|---|
| GNG7 protein expression analysis (group A) | GNG7 expression (−) vs (++) depending on the T stage (T = 1/2 vs T = 3/4) | T = 1/2 | T = 3/4 | 0.012* | |
| GNG7 (−) n = 40 | 9 (23%) | 31 (77%) | |||
| GNG7 (++) n = 22 | 12 (55%) | 10 (45%) | |||
| GNG7 expression (−) vs (++) depending on the N status (N = 0 vs N = 1/2/3) | N = 0 | N = 1/2/3 | 0.02* | ||
| GNG7 (−) n = 63 | 47 (75%) | 16 (25%) | |||
| GNG7 (++) n = 23 | 11 (48%) | 12 (52%) | |||
| GNG7 expression (−) vs (+) and (++) depending on keratinization (−) vs (+) | K (−) | K (+) | 0.008* | ||
| GNG7 (−) n = 27 | 17 (63%) | 10 (37%) | |||
| GNG7 (+/++) n = 29 | 8 (28%) | 21 (72%) | |||
| GNG7 promoter methylation analysis (group B) | GNG7 nonmethylated vs methylated depending on the age of patients (age ≤45 vs age >45) | age ≤45 n = 44 | age >45 n = 54 | < 0.001* | |
| GNG7 unmethylated | 15 (34%) | 41 (76%) | |||
| GNG7 methylated | 29 (66%) | 13 (24%) | |||
| GNG7 expression and promoter methylation | Loss of GNG7 expression vs methylation status | NO loss of expression | Loss of expression | < 0.001* (Yates' corrected) | |
| GNG7 unmethylated | 12 | 0 | |||
| GNG7 methylated | 3 | 10 | |||
T - size of the tumor
N = 0 - non nodular metastases
N = 1/2/3 - nodular metastases present
K(−) - no keratinization observed
K(+) - keratinization present
*statistically significant