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. 2012 Mar 1;33(5):1059–1064. doi: 10.1093/carcin/bgs116

Table II.

Top 30 SNPs associated to LC among the 1.655 SNPs in or nearby DNA repair genes

SNP Gene Pathway Chromosome Allele
 MAF
 Adjusted OR per allele 95% CI P
Minor Other Cases Controls
rs3131379 MSH5 MMR 6 A G 0.114 0.091 1.30 1.15–1.47 3.57 × 10−5
rs249633 MSH3 MMR 5 G A 0.258 0.241 1.18 1.08–1.29 2.18 × 10−4
rs1745335 POLN POL 4 A G 0.125 0.106 1.25 1.11–1.40 2.70 × 10−4
rs529966 POLN POL 4 G A 0.125 0.106 1.24 1.10–1.40 3.04 × 10−4
rs2736100 TERT POL 5 C A 0.515 0.476 1.15 1.07–1.24 3.07 × 10−4
rs9328764 POLN POL 4 A G 0.126 0.108 1.24 1.10–1.40 3.13 × 10−4
rs7659386 POLN POL 4 C T 0.126 0.108 1.24 1.10–1.40 3.31 × 10−4
rs4678 GTF2H4 NER 6 A G 0.231 0.200 1.18 1.08–1.30 3.51 × 10−4
rs10011549 POLN POL 4 T C 0.126 0.108 1.24 1.10–1.39 3.75 × 10−4
rs10018786 POLN POL 4 G T 0.126 0.108 1.24 1.10–1.39 4.09 × 10−4
rs6830513 POLN POL 4 C T 0.126 0.108 1.24 1.10–1.39 4.29 × 10−4
rs9534262 BRCA2 HR 13 T C 0.486 0.450 1.15 1.06–1.24 4.89 × 10−4
rs4942486 BRCA2 HR 13 T C 0.487 0.450 1.14 1.06–1.24 5.75 × 10−4
rs7893335 MMS19L NER 10 G T 0.148 0.166 0.85 0.76–0.94 1.47 × 10−3
rs206079 BRCA2 HR 13 A G 0.446 0.407 1.12 1.04–1.21 2.78 × 10−3
rs2236184 RAD51L1 HR 14 T C 0.307 0.291 1.14 1.04–1.23 2.79 × 10−3
rs6599418 POLN POL 4 A G 0.383 0.396 0.89 0.82–0.96 3.64 × 10−3
rs1012130 BRCA2 HR 13 C T 0.247 0.282 0.88 0.81–0.96 3.98 × 10−3
rs4899246 RAD51L1 HR 14 G A 0.219 0.204 1.15 1.04–1.26 3.99 × 10−3
rs7003908 PRKDC NHEJ 8 C A 0.370 0.353 1.12 1.04–1.22 4.04 × 10−3
rs10055011 POLK POL 5 A G 0.104 0.122 0.84 0.74–0.95 4.70 × 10−3
rs916962 RAD51L1 HR 14 A G 0.249 0.273 0.88 0.81–0.97 5.75 × 10−3
rs206319 BRCA2 HR 13 G A 0.344 0.317 1.12 1.03–1.21 5.95 × 10−3
rs2213178 PRKDC NHEJ 8 A G 0.312 0.301 1.12 1.03–1.22 5.97 × 10−3
rs618262 POLN POL 4 C A 0.061 0.051 1.26 1.07–1.49 6.79 × 10−3
rs3737559 BRCA1 HR 17 T C 0.090 0.106 0.84 0.74–0.95 7.19 × 10−3
rs13411119 FANCL SDA 2 A G 0.299 0.281 1.12 1.03–1.22 7.25 × 10−3
rs524051 POLN POL 4 A G 0.109 0.098 1.19 1.05–1.34 7.76 × 10−3
rs206120 BRCA2 HR 13 G A 0.186 0.166 1.14 1.03–1.26 8.62 × 10−3
rs11937432 POLN POL 4 G A 0.063 0.053 1.24 1.05–1.45 9.61 × 10−3

CI, confidence interval; MAF, minor allele frequencies; MMR: mismatch repair; NER, nucleotide excision repair; NHEJ, non-homologous end joining; P, P-value of the trend test of association adjusting for study, age, sex and tobacco smoking; POL, DNA polymerases.