Table III.

Overall and stratified results for SNP rs3131379 located in the MSH5 gene using unconditional logistic regression

Stratum	Sample size		A/G versus G/G genotype		A/A versus G/G genotype		Log-additive model		P
	Cases	Controls	OR	95% CI	OR	95% CI	OR	95% CI
Overalla	2607	4132	1.25	1.08–1.44	2.20	1.35–3.60	1.30	1.15–1.47	3.57 × 10−5
Sexb									0.27
Male	1887	2608	1.30	1.10–1.54	2.51	1.37–4.60	1.36	1.17–1.58
Female	720	1524	1.12	0.87–1.46	1.69	0.72–3.96	1.17	0.93–1.47
Agec (years)									0.98
≤50	379	1323	1.25	0.90–1.72	2.37	0.66–8.56	1.30	0.97–1.74
>50	2228	2806	1.24	1.06–1.45	2.16	1.27–3.65	1.29	1.13–1.48
Smoking statusd									0.99
Never-smokers	254	1608	1.24	0.87–1.76	2.47	0.75–8.14	1.31	0.95–1.79
Former smokers	513	984	1.16	0.85–1.57	2.88	1.14–7.23	1.30	1.00–1.68
Current smokers	1760	1389	1.28	1.04–1.57	2.11	1.01–4.41	1.32	1.10–1.58
Smoking quantityd									0.22
Non-smokers	254	1608	1.22	0.86–1.73	2.45	0.74–8.04	1.29	0.95–1.77
≤20	425	1180	1.02	0.75–1.38	1.39	0.51–3.85	1.06	0.81–1.38
>20	1863	1208	1.36	1.11–1.66	2.44	1.20–4.98	1.41	1.18–1.68
Histologye									9.10 × 10−3
Adenocarcinoma	580	3260	1.03	0.81–1.32	1.20	0.49–2.96	1.04	0.84–1.30
Squamous cell	907	3260	1.35	1.10–1.66	3.89	2.13–7.09	1.52	1.28–1.80
Others	807	3260	1.29	1.04–1.58	2.00	0.99–4.05	1.31	1.09–1.57

CI, confidence interval; P, P-value of trend test for the overall analysis and P-value for heterogeneity for the stratified analyses.

^aAdjusting for study, age, sex and smoking status (never/ever-smokers).

^bAdjusting for study, age and smoking status (never/ever-smokers).

^cAdusting for study, sex and smoking status (never/ever-smokers).

^dAdjusting for study, age, sex and pack-years (coded quantitatively).

^eAdjusting for study, age, sex and smoking status (never/ever-smokers).