Table V.
Top 15 genes associated to LC among the 211 DNA repair genes
| Gene | Pathway | Chromosome | Number of SNPs | P | Pcorrected |
| UBE2N | RPU | 12 | 7 | 3.25 × 10−8 | 6.86 × 10−6 |
| SMC1L2 | CHS | 22 | 11 | 1.70 × 10−6 | 3.59 × 10−4 |
| POLB | POL | 8 | 3 | 3.51 × 10−6 | 7.40 × 10−4 |
| RAD52 | HR | 12 | 9 | 6.14 × 10−5 | 1.29 × 10−2 |
| POLN | POL | 4 | 20 | 3.09 × 10−4 | 6.31 × 10−2 |
| BRCA2 | HR | 17 | 21 | 5.50 × 10−4 | 0.11 |
| MAD2L1 | CHS | 4 | 5 | 9.69 × 10−4 | 0.18 |
| FANCA | SDA | 16 | 9 | 2.72 × 10−3 | 0.44 |
| PRKDC | NHEJ | 8 | 5 | 2.75 × 10−3 | 0.44 |
| CHEK2 | CCR | 22 | 6 | 4.03 × 10−3 | 0.57 |
| TOPBP1 | TEL | 3 | 12 | 4.29 × 10−3 | 0.60 |
| DCLRE1B | NHEJ | 1 | 9 | 6.21 × 10−3 | 0.73 |
| RAD54L | HR | 1 | 4 | 7.02 × 10−3 | 0.77 |
| MSH4 | MMR | 1 | 11 | 7.10 × 10−3 | 0.78 |
| FANCJ | SDA | 17 | 11 | 8.10 × 10−3 | 0.82 |
CCR, cell cycle regulation; MMR, mismatch repair; NHEJ, non-homologous end joining; P, P-value of the gene-based association test adjusting for study, age, sex and tobacco smoking; Pcorrected, Dunn-Šidák-corrected P-value (211 tests); POL, DNA polymerases; TEL, telomerases, topoisomerases and accessory proteins.