Table VI.
Pathway-based association test results
| Acronym | Pathway | Number of genes | Number of SNPs | P | Pcorrected |
| CHS | Chromatin structure | 19 | 160 | 8.6 × 10−6 | 1.12 × 10−4 |
| POL | DNA polymerases | 22 | 165 | 2.1 × 10−5 | 2.73 × 10−4 |
| HR | Homologous recombination | 24 | 221 | 2.7 × 10−5 | 3.51 × 10−4 |
| SDA | Genes defective in diseases associated with sensitivity to DNA-damaging agents | 16 | 129 | 3.7 × 10−4 | 4.80 × 10−3 |
| RPU | Rad6 pathway and ubiquitination | 7 | 41 | 3.8 × 10−4 | 4.93 × 10−3 |
| NHEJ | Non-homologous end joining | 10 | 82 | 1.2 × 10−3 | 1.55 × 10−2 |
| TEL | Telomerases, topoisomerases and replicative accessory proteins | 28 | 213 | 3.5 × 10−3 | 4.46 × 10−2 |
| MMR | Mismatch repair | 11 | 88 | 6.3 × 10−3 | 0.08 |
| NER | Nucleotide excision repair | 23 | 161 | 1.3 × 10−2 | 0.16 |
| CCR | Cell cycle regulation | 22 | 162 | 3.2 × 10−2 | 0.34 |
| BER | Base excision repair | 20 | 137 | 0.12 | 0.81 |
| DRD | Direct reversal of damage | 3 | 56 | 0.16 | 0.90 |
| MNP | Modulation of nucleotide pool | 6 | 40 | 0.20 | 0.95 |
| Total | 211 | 1655 |
P: P-value of the pathway-based association test adjusting for study, age, sex and smoking status; Pcorrected, Dunn-Šidák-corrected P-value (13 tests).