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. Author manuscript; available in PMC: 2012 Apr 24.
Published in final edited form as: J Neuropathol Exp Neurol. 2008 Aug;67(8):773–783. doi: 10.1097/NEN.0b013e318180ec47

Figure 1.

Figure 1

Figure 1

Age-related changes in expression of βAPP and ApoE. (A) βAPP (green) and ApoE (red) were detected by immunofluorescence in tissue sections from hippocampus at the level of the lateral geniculate nucleus. Results are shown for 4 non-demented individuals across an age span of 46 to 80 years. Blue represents DAPI staining of cellular DNA. Images were digitized at 20× magnification. Scale bar represents 20 μm. (B) Quantitation of βAPP and ApoE immunofluorescence intensity was obtained by thresholding βAPP grayscale images and integrating pixels as described in Materials and Methods. Values reflect the mean of 3 images per hippocampus of 6 (ApoE) or 8 (βAPP) non-demented individuals.